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Prime Retail or Office For Lease

290 Sergeant Prentiss Dr, Natchez, MS 39120

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Overview

Premier leasing opportunity in one of Natchez’s most visible and well-traveled areas. This versatile property is ideal for retail, office, or medical use, offering a flexible layout and updated finishes that make it perfectly suited for a variety of business types seeking strong exposure and a professional image.

  • Additional +/- 2,200 SF of unfinished space available for build out
  • Daily vehicle traffic +/- 24,000
  • Wall to wall frontage display windows
  • 2 breakrooms / offices and 2 bathrooms

Lease Spaces

NameRateSFVacantAvailable DateStatus
Suite ANegotiable3,100 SFYes10/14/2025available

For Lease

Retail
Office

Secondary Uses: Mixed Use

Lease Rate
Negotiable
Available SF
3,100 SF
Acres
0.9938 ac
Zoning Desc.
Highway Business District
Lease Type
Gross
Signage
On Building and Pylon
Showing
Lockbox
County
Adams
Available
10/14/2025
Listed
10/30/2025
Updated
12/20/2025
Listing ID
8269c754
Parcel APN
40-113A-10.1